膳食炎症指数与子宫内膜癌|膳食维生素与癌症研究系列(二)

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目前，对于膳食引起的炎症反应与子宫内膜癌风险之间的关系，还少有相关的调查报道。

The relation between inflammation deriving from diet and endometrial cancer risk has not yet been investigated.

在本研究中，我们通过进行一项意大利病例对照研究，探索了膳食炎症指数（dietary inflammatory index, DII）与子宫内膜癌风险之间的相关性。

In this study, we explored the association between the dietary inflammatory index (DII) and endometrial cancer risk in an Italian case-control study.

病例组由454名已经确诊的子宫内膜癌患者组成，对照组则由908名来自相同医院的各种急性非肿瘤疾病患者组成。DII评分以膳食摄入评估问卷为基础，此问卷可重复使用，经评估里面78个有效的项目计算得出最后DII的分数。比值比（OR）的计算基于以年龄和学习中心为条件的逻辑回归模型，并消除已知的混杂因素（包括总能量摄入）。

Cases comprised 454 patients with incident, histologically confirmed carcinoma of the endometrium, and controls comprised 908 subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. DII scores were computed on the basis of dietary intake assessed using a reproducible and valid seventy-eight-item FFQ. OR were calculated through logistic regression models conditioned on age and study centre and adjusted for recognised confounding factors, including total energy intak.

吃最容易引起炎症饮食的女性，与吃抗炎症能力最强饮食的女性相比，其得子宫内膜癌的风险更高（OR四分位4v.1 1.46；95%置信区间：1.02，2.11；P=0.04）。

Women with the most pro-inflammatory diet had a higher risk for endometrial cancer compared with women with the most anti-inflammatory diet (ORQuartile 4 v. 1 1.46; 95 % CI 1.02, 2.11; P trend=0.04).

促炎症饮食可能会增加子宫内膜癌的患病风险。

A pro-inflammatory diet may increase the risk for endometrial cancer.